20-mg tab Adult & adolescent ≥12 yr Symptomatic GERD 20 mg/day.
Long-term management & prevention of relapse in reflux oesophagitis 20 mg/day, increasing to 40 mg/day if a relapse occurs. After healing of the relapse, dose can be reduced to 20 mg.
Adult Prevention of gastroduodenal ulcers induced by NSAIDs 20 mg/day.
Patients w/ severe liver impairment Max: 20 mg daily.
40-mg tab Adult & adolescent ≥12 yr Reflux oesophagitis 1 tab (40 mg) daily, may be increased to 2 tab daily.
Adult Eradication of H. pylori in combination w/ 2 appropriate antibiotics 1 tab pantoprazole bd + amoxicillin 1,000 mg bd + clarithromycin 500 mg bd; or 1 tab pantoprazole bd + metronidazole 400-500 mg bd (or tinidazole 500 mg) + clarithromycin 250-500 mg bd; or 1 tab pantoprazole bd + amoxicillin 1,000 mg bd + metronidazole 400-500 mg bd (tinidazole 500 mg).
Gastric ulcer 1 tab/day, may be increased to 2 tab daily.
Duodenal ulcer 1 tab/day, may be increased to 2 tab daily.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions 80 mg (2 tab) daily. Thereafter, dose can be titrated up or down as needed. Doses >80 mg daily should be divided & given bd.